Protein variety and functional diversity:
Swiss-Prot annotation in its biological context

Brigitte Boeckmann, Marie-Claude Blatter, Livia Famiglietti, Ursula Hinz, Lydie Lane, Bernd Roechert, Amos Bairoch

C. R. Biologies 328:882-899(2005)
Updated version (Sep-2007)

Annotation examples



The UniProtKB/Swiss-Prot Protein Knowledgebase is a manually annotated protein sequence database which provides a wealth of information regarding protein variety, protein function and associated disorders. An article in C. R. Biologies gives an overview on cellular processes that can lead to sequence variety and structural diversity in eukaryotes, as well as how such processes are annotated in UniProtKB/Swiss-Prot. The many examples given therein can be accessed below: the UniProtKB/Swiss-Prot examples (dark blue) are linked via their accession numbers to the most recent version of the database entries (UniProt web site view); the same entry in the original UniProtKB/Swiss-Prot raw format is provided. Terms in light blue indicate the annotation topics, under which the information of interest can be found in the UniProtKB/Swiss-Prot entry. Other links provide lists of further examples via queries, using specific keywords, combination of keywords and/or other annotation.

Note: The ongoing evolution of the database can lead to changes in the annotation, thus the examples might differ soon from those printed in the corresponding article. Recent changes and forthcoming changes of UniProtKB are announced. Details on the format of UniProtKB/Swiss-Prot entries are provided in the user manual.

Formation of the nascent protein sequence

Protein sorting and associated sequence modifications

Protein folding and structure

Function-related protein modifications (PTMs)

Protein-protein interaction

Protein function and disease-association