French version
Atelier 5 - Coronavirus and Proteins...
Since December 2019, a new coronavirus of animal origin started to infect humans: this is the beginning of a pandemic
This new virus is called Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2).
He is responsible for the disease called Coronavirus disease-19 (COVID-19).
Objectives
- Discover viruses and SARS-CoV-2
- Discover bioinformatic databases - GenBank (DNA), UniProtKB (protein), PDB (3D structure), Viralzone
- Discover bioinformatic tools (Blast, BLAT, align, translate)
- Better understand current research... and the challenges faced!
Prerequisite
1.- Introduction
- What is a virus ?- Viruses that infect humans ?
-
2.- SARS-CoV-2's genome
- The DNA sequence of SARS-CoV-2 -
Exercise: compare the DNA sequences of SARS-CoV-2 coming from
different countries...
- Specificity
of the PCR assay - Exercise:
test the primers used for the PCR...
3.- SARS-CoV-2's proteins
- From genome to proteins- SARS-CoV-2 and its protein Spike
- Exercise:
translate a nucleotide sequence to an amino acid sequence
- Exercise:
from the protein sequence to its 3D structure
- How
does the virus enter human cells?4.- Looking for the origins of SARS-CoV-2
- Coronaviruses that infect other mammals - Exercise:
which coronavirus is the most 'similar' to SARS-CoV-2?
- Exercise:
compare the Spike protein of other coronavirus (civet, pangolin, bat,
...)
5.- In search of a treatment
- Drugs or vaccines?6.- SARS-CoV-2 and HIV
- An example of fake news-
Exercise: look for HIV sequences in SARS-CoV-2's genome
7 - Latest news
- About mRNA vaccines (BioNTech/Pfizer and Moderna)- About UK viral lineage (B.1.1.7)
- About South Africa viral lineage (501Y.V2)
How to contact us...
This workshop is the result of a collaboration between L'éprouvette, University of Lausanne's public laboratory (Service Culture et Médiation Scientifique) and the Swiss-Prot group - SIB Swiss Institute of Bioinformatics.We can run this workshop in your classrooms or online : do not hesitate to contact us!
- outreach@sib.swiss
About us...
License & disclaimer
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