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Atelier 5 - Coronavirus and Proteins...




Since December 2019, a new coronavirus of animal origin started to infect humans: this is the beginning of a pandemic
This new virus is called Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2).
He is responsible for the disease called Coronavirus disease-19 (COVID-19).

Objectives
Prerequisite

1.- Introduction

- What is a virus ?
- Viruses that infect humans ?
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2.- SARS-CoV-2's genome

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The DNA sequence of SARS-CoV-2
- Exercise: compare the DNA sequences of  SARS-CoV-2 coming from different countries...
- Specificity of the PCR assay
- Exercise: test the primers used for the PCR...

3.- SARS-CoV-2's proteins

- From genome to proteins
- SARS-CoV-2 and its protein Spike
- Exercise: translate a nucleotide sequence to an  amino acid sequence 
- Exercise: from the protein sequence to its 3D structure
- How does the virus enter human cells?

4.- Looking for the origins of SARS-CoV-2

- Coronaviruses that infect other mammals
- Exercise: which coronavirus is the most 'similar' to SARS-CoV-2?
- Exercise: compare the Spike protein of other coronavirus (civet, pangolin, bat, ...)

5.- In search of a treatment

- Drugs or vaccines?
- Exercise: An example of research carried out at the SIB...

6.- SARS-CoV-2 and HIV

- An example of fake news
- Exercise: look for HIV sequences in SARS-CoV-2's genome


How to contact us...

This workshop is the result of a collaboration between L'éprouvette, University of Lausanne's public laboratory (Service Culture et Médiation Scientifique) and the Swiss-Prot group - SIB Swiss Institute of Bioinformatics.

We can run this workshop in your classrooms or online : do not hesitate to contact us!

About us...

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