Atelier 5 - Coronavirus and Proteins...

Since December 2019, a new coronavirus of animal origin started to infect
humans: this is the beginning of a pandemic
This new virus is called Severe Acute Respiratory Syndrome-related
Coronavirus 2 (
SARS-CoV-2).
He is responsible for the disease called Coronavirus disease-19 (
COVID-19).
Objectives
Prerequisite
1.- Introduction
-
What is
a virus ?
-
Viruses
that infect humans ?
-
2.- SARS-CoV-2's genome
- The
DNA sequence of SARS-CoV-2
-
Exercise: compare the DNA sequences of SARS-CoV-2 coming from
different countries...
-
Specificity
of the PCR assay
- Exercise:
test the primers used for the PCR...
3.- SARS-CoV-2's proteins
-
From
genome to proteins
-
SARS-CoV-2
and its protein Spike
- Exercise:
translate a nucleotide sequence to an amino acid sequence
- Exercise:
from the protein sequence to its 3D structure
-
How
does the virus enter human cells?
4.- Looking for the
origins of SARS-CoV-2
-
Coronaviruses
that infect other mammals
- Exercise:
which coronavirus is the most 'similar' to SARS-CoV-2?
- Exercise:
compare the Spike protein of other coronavirus (civet, pangolin, bat,
...)
5.- In
search of a treatment
-
Drugs
or vaccines?
6.-
SARS-CoV-2 and HIV
-
An
example of fake news
-
Exercise: look for HIV sequences in SARS-CoV-2's genome
7 - Latest
news
-
About
mRNA vaccines (BioNTech/Pfizer and Moderna)
-
About
UK viral lineage (B.1.1.7)
-
About
South Africa viral lineage (501Y.V2)
How to contact us...
This workshop is the result of a collaboration between
L'éprouvette,
University of Lausanne's public laboratory (Service Culture et Médiation
Scientifique) and the
Swiss-Prot group - SIB Swiss
Institute of Bioinformatics.
We can run this workshop in your classrooms or online : do not hesitate to
contact us!
About us...
License & disclaimer
This portal is licensed under a
Creative
Commons Attribution-NonCommercial 4.0 International License.
